STUDIES IN AMINO ACID METABOLISM

Amino Acid Metabolism

AB S T R A C T To evaluate the factors regulating gluconeogenesis in pregnancy, plasma amino acid levels were determined during the course of an 84-90 hr fast in physically healthy women studied during wk 16-22 of gestation (before undergoing therapeutic abortion), and in nonpregnant controls. The effect of pregnancy on the glycemic response to exogenous alanine administration during starvation...

Malnutrition and Amino Acid Metabolism

Severe childhood malnutrition embraces a spectrum of clinical presentations and pathologic disorders. Across the entire spectrum, there is clear evidence of major changes in the state of amino acid and whole body protein metabolism, from the skeletal wasting and stunting of marasmus to the varied multisystem changes characterized by the kwashiorkor syndrome. For this reason, amino acid and prot...

Amino acid metabolism in locust tissues.

Amino acid metabolism in exercising man.

Arterial concentration and net exchange across the leg and splanchnic bed of 19 amino acids were determined in healthy, postabsorptive subjects in the resting state and after 10 and 40 min of exercise on a bicycle ergometer at work intensities of 400, 800, and 1200 kg-m/min. Arterio-portal venous differences were measured in five subjects undergoing elective cholecystectomy. In the resting stat...

Amino acid metabolism in tumour-bearing mice.

Mice bearing the Lewis lung carcinoma showed a high tumour glutaminase activity and significantly higher concentrations of most amino acids than in both the liver and the skeletal muscle of the host. Tumour tissue slices showed a marked preference for glutamine, especially for oxidation of its skeleton to CO2. It is proposed that the metabolism of this particular carcinoma is focused on amino a...